Mucosal - Ophthalmic Drug Delivery

Liquigel Dosage Form

  • Although PharmaDur® polymer is water-insoluble, it can be mechanically dispersed in saline or water to form an almost clear apparent solution with a slight bluish haze.    If the drug is water-soluble, it may be dissolved in the polymer solution.   If the drug is water-insoluble, it may be dispersed in the solution by homogenizing its micronized form in the polymer solution.  PharmaDur® forms polymeric micelles in water, resulting in extremely stable drug dispersions.

  • Performance Attributes

    PharmaDur® polymer exhibits a unique combination of outstanding mucoadhesion and controlled drug delivery capability, which can provide long-term pharmacological activity.

PharmaDur® Advantage
  • Improved bioavailability of the drug. 
  • Potential for once/day dosing.
  • Surfactant-free and oil-free, milk-like dispersions of water-insoluble drugs. 
  • Reduced irritation potential of the drug.

Product Opportunities
  • Glaucoma Therapy (e.g. cabonic anhydrase inhibitor).
  • Anti-infectives (e.g. fluoroquinolones).
  • Dry Eye (cyclosporine).
  • Anti-inflammatory (e.g. prednisalone acetate; dexamethasone).