Mucosal - Other

IN SITU GELLING N0N-AQUEOUS SOLUTION

A particularly appealing dosage form of PharmaDur® compositions is a non-aqueous liquid vehicle, which undergoes in situ gelation at the mucosal site of application to form a soft, mucosal tissue adherent gel.  The liquid PharmaDur® dosage form can be formulated so that it easily flows initially to provide the desired coverage of the mucosal surface, and then quickly gel without any chemical reactions.

KEY PERFORMANCE ATTRIBUTES
  • Initially Flows, Quickly Gels, Adheres to Mucosa
  • Prolonged Residence Time at the Site of Application
  • Sustained Drug Release for Topical or Systemic Activity

Enhances Effectiveness, Safety & Compliance


Selected Product Opportunities
  • Nasal Delivery of Therapeutic Agents
  • Drug Delivery to the Oral Mucosa
  • Long Acting Topical Treatment (Phenylephrine, Analgesic, or Steroid) for Hemorrhoids and Anal Fissures
  • Long Acting Vaginal Preparations (e.g. microbicides, antifungal, steroids, anti-itch)
  • Long Acting Spermicidal Preparation (e.g. Nonoxynol-9)